Open Positions
Would you like to join the Flowers Lab team? We would love to hear from you.
Postdoctoral Research Associate Position, Mass spectrometry-focused position.
The Department of Neuroscience at the University of Virginia School of Medicine seeks a mass spectrometry focused Postdoctoral Research Associate to join the lab of Dr. Sarah Flowers. The Flowers Lab (flowerslab.org) is focused on Alzheimer’s disease with an interest in APOE, the most significant genetic risk factor for sporadic AD. We utilize mass spectrometry to understand how carbohydrate modifications are altered in AD, and use induced pluripotent stem cells and clinical samples to harness this knowledge for the identification of AD before pathology as well as therapeutic targets to stop the progression to AD. The lab is NIH-funded and equipped with state-of-the-art instrumentation.
Our new lab member will join and contribute to a welcoming and supportive environment driven to carry out fundamental and translational research to improve AD patient outcomes. UVA is home to a strong and connected Postdoc community and the successful candidate will have support from the Flowers Lab, the Department of Neuroscience, the Center for Brain Immunology and Glia, and a wide array of UVA programs for professional development. They will expand their MS and biochemistry skills, become confident in the AD field, and improve grant and manuscript writing skills.The successful candidate will have the following qualifications and experience. A PhD in Biochemistry, Biophysics, Neuroscience or related field conferred by the start date. Experience with Mass spectrometry sample preparation, instrumentation operation and method development preferably using Sciex instrumentation, and data analysis. Previous research experience focused on quantitative mass spectrometry, glycomics, glycoproteomics or advanced glycation end products is ideal. Previous experience in Alzheimer’s disease, APOE research or carbohydrate cell metabolism would be highly regarded. The ability to work independently, collaborate with a range of scientists and work as part of a diverse and supportive group is essential.
MORE INFORMATION AND APPLY - https://uva.wd1.myworkdayjobs.com/UVAJobs/job/Charlottesville-VA/Research-Associate--Department-of-Neuroscience_R0048696
Lab Specialist Intermediate
The Flowers Lab in the Department of Neuroscience in the University of Virginia School of Medicine seeks a Lab Specialist Intermediate. The Flowers Lab (flowerslab.org) is focused on understanding the very early stages of Alzheimer’s disease pathogenesis, and using this knowledge for the effective diagnosis and treatment of AD. One of the main focuses of the Flowers lab is understanding the impact of the glycoprotein, APOE, on the early pathogenesis of Alzheimer’s disease (AD). APOE is the most significant genetic risk factor for Alzheimer’s disease, despite this, there is a lot we do not understand about how APOE conveys this risk. We use human induced pluripotent cells (iPSCs) and advanced technologies including mass spectrometry to better understand the changes that occur in AD. The Lab Specialist Intermediate will aid us with this important work.
This individual will be responsible for and help facilitate research related to understanding the significance of APOE and its glycosylation to Alzheimer’s disease pathogenesis. They will be responsible for the culturing and differentiation of iPS cells into a range of cell types as well as carrying out cell, biochemical, and molecular biology assays. They will prepare samples for mass spectrometric analyses and work with a range of patient and iPSC-derived samples. The candidate will work with other members of the group invested in this project to maintain cells, carry out experiments, analyze data, as well as document and report on results to the group. A smaller part of this role will involve routine but important lab maintenance and administration tasks.
MORE INFORMATION AND APPLY - https://uva.wd1.myworkdayjobs.com/UVAJobs/job/Charlottesville-VA/Lab-Specialist-Intermediate--Department-of-Neuroscience_R0047719